Bioinformatics
24CSE645 · S6 · 4 credits
Official KTU 2024 syllabus subject — study with practice, PYQs and AI tools.
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Why:Foundation module
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Why:Core module
Why:Applied concepts
Why:Standard exam coverage
Module 01Introduction to bioinformatics (8 hours)expand
Introduction to bioinformatics - Nature and Scope, DNA, RNA, and Protein. The Central Dogma of Molecular Biology, Messenger RNA, tRNA, rRNA, Genetic code. Introduction to Biological Databases, NCBI, Genbank, Bio sequence formats- FASTA. Introduction to Bio-programming Languages.
Module 02Bio sequences and analysis (8 hours)expand
Sequence alignment- Global Alignment and Local Alignment, Dot Matrix Method, Dynamic Programming Method, Needleman and Wunsch and Smith–Waterman Algorithms, Gap Penalties, Amino Acid Scoring Matrices - PAM and BLOSUM. Multiple Alignment.
Module 03Molecular Phylogenetics (7 hours)expand
Motif finding, Gene Prediction, Molecular Phylogenetics, Phylogenetic trees, Algorithms for Phylogenetic Tree construction – UPGMA, Neighbour Joining. Small Parsimony Problem, Large Parsimony Problem.
Module 04Combinatorial Pattern Matching (6 hours)expand
Combinatorial Pattern Matching, Repeat finding, Keyword Trees, Suffix Trees, Heuristic similarity search algorithms, Approximate Pattern Matching.
Module 05Genomics and Proteomics (7 hours)expand
Protein structure basics- visualization, comparison, and classification. Functional Genomics- Gene expression, Analyzing Gene Expression Data- EST, SAGE- Microarrays. Proteomics- Technology of Protein Expression Analysis.
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